Current Research in MRI
Original Article

The Role of Multiparametric Scrotal Magnetic Resonance Imaging in the Histological Differentiation of Germ Cell Neoplasia In Situ-Related Testicular Germ Cell Tumors: Can Seminomatous and Mixed-Non-Seminomatous Germ Cell Tumors Be Separated?

1.

Department of Radiology, Giresun University Faculty of Medicine, Giresun, Turkey

2.

Department of Urology, Giresun University Faculty of Medicine, Giresun, Turkey

3.

Department of Radiology, Samsun Education and Research Hospital, Samsun, Turkey

Curr Res MRI 2023; 2: 63-69
DOI: 10.5152/CurrResMRI.2023.23078
Read: 397 Downloads: 176 Published: 30 October 2023

Objective: The aim was to examine the efficacy of multiparametric magnetic resonance imaging (mp-MRI) in the histological differentiation of germ cell neo- plasia in situ (GCNIS)-related testicular germ cell tumors (TGCTs).

Methods: We retrospectively included 58 patients with histologically proven GCNIS-related TGCTs, who underwent mp-MRI between November 2019 and June 2022. The signal characteristics of the tumors on T2-weighted imaging were recorded. The mean apparent diffusion coefficient (ADC) values were calcu- lated. Time signal intensity curves were generated, and semiquantitative parameters were calculated. The presence of a septal enhancement pattern within the tumor was noted. Receiver operating characteristic curve analysis was performed to assess the diagnostic performance of the parameters.

Results: Histopathological examination revealed that 24 of the cases were seminomas, and 10 were non-seminomatous GCT (NSGCTs). The incidence of hypointense signals was notably higher for seminomas (P < .001). The mean ADC values of the seminomas were lower than NSGCTs (0.645 ± 0.11 and 0.879 ± 0.061, respectively, P < .001). The optimal ADC cutoff value was 0.779 × 10−3 mm2/s. No differences were observed between the 2 groups for semiquantitative parameters (P = .16-.83). However, the septal enhancement pattern was more frequent in seminomas (P = .002).

Conclusion: Values of ADC measured in mp-MRI can be used as a reliable preoperative method in the histological differentiation of GCNIS-related TGCTs. Also, the septal enhancement pattern can be helpful in distinguishing between seminoma and NSGCT.

Cite this article as: Aslan S, Eryürük U, Oğuz U, Çakır İM. The role of multiparametric scrotal Magnetic Resonance Imaging in the histological differentiation of germ cell neoplasia insitu-related testicular germ cell tumors: Can seminomatous and mixed-non-seminomatous germ cell tumors be separated? Current Research in MRI 2023;2(3):63-69.

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